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Chemo-enzymatic transformation of taxanes and the evaluation of their mdr reversal activity towards tumor

  • At: 2007 FIP Congress in Beijing (China)
  • Type: Poster
  • By: DAI, Jun (Institute of Medical Science, Beijing, China)
  • Co-author(s): Qu, Runjiang (Institute of Medical Science, BEIJING, China)
    Chen, Xiaoguang (Institute of Medical Science, BEIJING, China)
    Zou, Jianhua (Institute of Medical Science, BEIJING, China)
  • Abstract:

    A 'small taxane library' was established through chemo-enzymatic transformation of the taxanes derived from cell cultures of Taxus chinensis. The MDR reversal activity towards tumor and cytotoxicity of most these compounds were evaluated, and several derivatives exhibited powerful MDR reversal activity and low cytotoxicity. The structure-activity..

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Last update 4 October 2019

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