Total body clearance of ritodrine during of twin pregnancy

• In: SIG Bioavailability/Bioequivalence - Posters
• At: Beijing (China) (2007)
• Type: Poster
• Poster code: BB-P-007
• By: KONDA, Ainari (Tenshi Hospital, Sapporo, Japan)
• Co-author(s): Akiko, Nodai (Tenshi Hospital, SAPPORO, Japan)
  Mayuko, Soma (Tenshi Hospital, SAPPORO, Japan)
  Yasutsugu, Koga (Tenshi Hospital, SAPPORO, Japan)
  Hiroshi, Yoshida (Tenshi Hospital, SAPPORO, Japan)
  Takaki, Toda (Hokkaido Pharmaceutical Univerisity, OTARU, Japan)
  Toru, Hayakawa (Hokkaido Pharmaceutical Univerisity, OTARU, Japan)
  Nobuo, Inotsume (Hokkaido Pharmaceutical Univerisity, OTARU, Japan)
  
• Abstract:

  Physiological factors such as increases of blood capacity and kidney blood flow and a change of drug metabolism activity have been demonstrated during pregnancy, lead to pharmacokinetic changes of drugs.
  
  
  
  Ritodrine, a tocolytic beta-agonist, has been used in life-threatening premature delivery in Japan since 1986. Dosage adjustment of ritodrine..

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