Relationship of P450 2C9 genetic polymorphisms in Chinese and the pharmacokinetics of tolbutamide

• At: 2007 FIP Congress in Beijing (China)
• Type: Poster
• By: CHEN, Kun (Chinese PLA General Hospital, Beijing, China)
• Co-author(s): Wang, Rui (Chinese PLA General Hospital, BEIJING, China)
  Ji, Xiaolong (Chinese PLA General Hospital, BEIJING, China)
  
• Abstract:

  Abstract AIM: To study the relationship of P450 2C9 genetic polymorphisms and the pharmacokinetics of tolbutamide in Chinese. METHODS: P450 2C9 genotype was determined by oligonucleotide microarray. Using tolbutamide as a probe of P450 2C9 activity, P450 2C9 phenotype in 63 healthy individuals expressing the P450 2C9*1/*1, *1/*3 and *3/*3

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