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GASTRORETENTIVE FLOATING LIPID BASED RANTIDINE HCL MICROPARTICULATES : DEVELOPMENT AND IN–VITRO EVALUATION

  • At: 2015 FIP Congress in Düsseldorf (Germany)
  • Type: Poster
  • By: ETMAN, Mohamed (Faculty of Pharmacy, University of Alexandria, Department of Pharmaceutics, Alexandria, Egypt)
  • Co-author(s): Mohamed A Etman
  • Abstract:

    Rantidine is only absorbed in the initial part of small intestine and has 50% absolute bioavailability and short half life ( ~ 2.5 – 3h ). A gastroretentive sustained release formulation would be favorable.

    Melt granulation technique using lipids (compritol ATO , Cutina GMS , hydrogenated castor oil (cutina HR) and bess wax was applied. Seived drug

    ..

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Last update 4 October 2019

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