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Pre-systemic Chiral Inversion of Ibuprofen in Rabbits and Humans

  • At: 2007 FIP Congress in Beijing (China)
  • Type: Poster
  • By: INOTSUME, Nobuo (Hokkaido Pharmaceutical University, OTARU, Japan)
  • Co-author(s): Hayakawa, Toru (Hokkaido Pharmaceutical University, OTARU, Japan)
    Obara, Takako (Hokkaido Pharmaceutical University, OTARU, Japan)
    Yanaguimoto, Hitomi (Hokkaido Pharmaceutical University, OTARU, Japan)
    Toda, Takaki (Hokkaido Pharmaceutical University, OTARU, Japan)
    Fukushima, Shoji (Kobe Gakuin University, KOBE, Japan)
    Kishimoto, Shuichi (Kobe Gakuin University, KOBE, Japan)
    Lin, Wenhui (Shenyang Pharmaceutical University, SHENYANG, China)
    Cui, Fude (Shenyang Pharmaceutical University, SHENYANG, China)
    Liu, Yang (Heilongjiang Provincial Second Hospital, HARBIN, China)
    Sun, Jiewen (Heilongjiang Provincial Second Hospital, HARBIN, China)
    Ding, Guohua (Heilongjiang Provincial Second Hospital, HARBIN, China)
  • Abstract:

    Ibuprofen, a non-steroidal anti-inflammatory drug, is used worldwide mainly in the form of racemate. Ibuprofen contains one chiral center and R(-)-ibuprofen, the distomer, has been demonstrated to undergo unidirectional conversion to S(+)-ibuprofen, the eutomer, in vivo. Thus, S(+)-enantiomer is considered to play an important role in its clinical ..

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Last update 4 October 2019

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