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DEVELOPMENT OF SIMULTANEOUS QUANTIFICATION OF FREE ITRACONAZOLE AND HYDROXY ITRACONAZOLE IN HUMAN PLASMA USING ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY.

  • At: 2015 FIP Congress in Düsseldorf (Germany)
  • Type: Poster
  • By: OYAMA, Nobuhiro (Oita University Hospital, Clinical Pharmacy, Yufu, Japan)
  • Co-author(s): Nobuhiro Oyama
  • Abstract:

    Itraconazole (ITCZ) is a common triazole antifungal drug used for the treatment and prevention of fungal infections, and hydroxyl itraconazole (OH-ITCZ) which is a main metabolite of ITCZ, is reported to have antifungal activity. There are several reviews to determine concentrations of ITCZ and OH-ITCZ in human plasma, but free concentrations of..

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Last update 4 October 2019

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