PREPARATION, CHARACTERIZATION AND SYSTEMATIC OPTIMIZATION OF IMATINIB-LOADED NANOSTRUCTURED LIPID CARRIERS USING A HYBRID EXPERIMENTAL DESIGN APPROACH
- At: 2015 FIP Congress in Düsseldorf (Germany)
- Type: Poster
- By: TAK, Jin Wook (Yeungnam University, Daegu, South-Korea)
- Co-author(s): Jin, Wook Tak (, South-Korea)
Imatinib (IMT), a specific inhibitor of Bcr-Abl, PDGFR and c-Kit, exhibits low aqueous solubility, extensive first pass metabolism and rapid renal clearance. Nanostructured lipid carriers (NLCs) are capable of enhancing aqueous solubility, permeability and bioavailability of drugs. Design of experiments (DoE) facilitates identification of all.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.