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PREPARATION, CHARACTERIZATION AND SYSTEMATIC OPTIMIZATION OF IMATINIB-LOADED NANOSTRUCTURED LIPID CARRIERS USING A HYBRID EXPERIMENTAL DESIGN APPROACH

  • At: 2015 FIP Congress in Düsseldorf (Germany)
  • Type: Poster
  • By: TAK, Jin Wook (Yeungnam University, Daegu, South-Korea)
  • Co-author(s): Jin, Wook Tak (, South-Korea)
  • Abstract:

    Imatinib (IMT), a specific inhibitor of Bcr-Abl, PDGFR and c-Kit, exhibits low aqueous solubility, extensive first pass metabolism and rapid renal clearance. Nanostructured lipid carriers (NLCs) are capable of enhancing aqueous solubility, permeability and bioavailability of drugs. Design of experiments (DoE) facilitates identification of all

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Last update 4 October 2019

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