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FORMULATION AND EVALUATION OF COMBINED BACLOFEN AND TIZANIDINE HYDROCHLORIDE TRANSDERMAL PATCHES

  • At: 2015 FIP Congress in Düsseldorf (Germany)
  • Type: Poster
  • By: CHUN, In Koo (Dongduk Women's University, College of Pharmacy, Seoul, South-Korea)
  • Abstract:

    Baclofen (BC) inhibits GABA receptor, whereas tizanidine hydrochloride (TZ) effects on α2 receptor to hinder neurotransmitter release. Both drugs are muscle relaxants and antispastic drugs, but have short half-lives and low bioavailabilities, and are orally administered three times a day.

    To select vehicles for BC and TZ, solubility studies were

    ..

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Last update 4 October 2019

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