FORMULATION AND EVALUATION OF COMBINED BACLOFEN AND TIZANIDINE HYDROCHLORIDE TRANSDERMAL PATCHES
- At: 2015 FIP Congress in Düsseldorf (Germany)
- Type: Poster
- By: CHUN, In Koo (Dongduk Women's University, College of Pharmacy, Seoul, South-Korea)
Baclofen (BC) inhibits GABA receptor, whereas tizanidine hydrochloride (TZ) effects on α2 receptor to hinder neurotransmitter release. Both drugs are muscle relaxants and antispastic drugs, but have short half-lives and low bioavailabilities, and are orally administered three times a day.
To select vehicles for BC and TZ, solubility studies were.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.