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IDENTIFICATION OF A NOVEL NAMPT INHIBITOR BY COMBINATORIAL CLICK CHEMISTRY

  • At: 2015 FIP Congress in Düsseldorf (Germany)
  • Type: Poster
  • By: THEERAMUNKONG, Sewan (Thammasat University, Pathum Thani, Thailand)
  • Co-author(s): Sewan Theeramunkong
  • Abstract:

    Nicotinamide phosphoribosyl transferase (NAMPT) is a key enzyme in NAD metabolism most frequently up-regulated in metabolic, inflammatory and tumoral states. To date, only FK866 and CHS828 have reached clinical trials in cancer but both of them have shown low bioavailability and some side effects. A recent pre-clinical study also suggests that the

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Last update 4 October 2019

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