IDENTIFICATION OF A NOVEL NAMPT INHIBITOR BY COMBINATORIAL CLICK CHEMISTRY
- At: 2015 FIP Congress in Düsseldorf (Germany)
- Type: Poster
- By: THEERAMUNKONG, Sewan (Thammasat University, Pathum Thani, Thailand)
- Co-author(s): Sewan Theeramunkong
Nicotinamide phosphoribosyl transferase (NAMPT) is a key enzyme in NAD metabolism most frequently up-regulated in metabolic, inflammatory and tumoral states. To date, only FK866 and CHS828 have reached clinical trials in cancer but both of them have shown low bioavailability and some side effects. A recent pre-clinical study also suggests that the.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.