COMPARISON OF DISSOLUTION PROFILES FOR DONEPEZIL HYDROCHLORIDE FROM IMMEDIATE RELEASE FORMULATIONS USING THE PADDLE AND FLOW-THROUGH METHOD
- At: 2015 FIP Congress in Düsseldorf (Germany)
- Type: Poster
- By: STECOZA, Cristina (University of Medicine and Pharmacy „Carol Davila”, Faculty of Pharmacy, Center for Drug Sciences, 6 Traian Vuia street, 020956, Bucharest, Romania)
- Co-author(s): Cristina Gabriela Stecoza
For very rapidly dissolving products, the flow-through apparatus can provide valuable data on the initial phases of the dissolution process.
The paddle method was applied using 900mL of media with pH 1.2 to 7.2 at 50rpm. An alternative test was implemented, with gradual increase of the pH, assessing the potential precipitations of the drug in the.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.