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Accounting for ethnic and sex differences in qtc prolongation using heart drug concentrations with physiologically based pharmacokinetic/pharmacodynamic (pbpk/pd) models

  • At: 2014 FIP Congress in Bangkok (Thailand)
  • Type: Poster
  • By: CHETTY, Manoranjenni (Simcyp Ltd (A Certara company), Sheffield, United Kingdom)
  • Co-author(s): Polak, Sebastian (Simcyp Ltd (A Certara company), Sheffield, United Kingdom)
    Jamei, Masoud (Simcyp Ltd (A Certara company), Sheffield, United Kingdom)
    Rostami, Amin (Simcyp Ltd (A Certara company), Sheffield, United Kingdom)
  • Abstract:

    I. Background: Ethnic and sex differences in QTc prolongation are poorly understood.
    II. Aims: To develop a PBPK/PD model linking unbound quinidine concentrations in the heart to QT prolongation for comparison of quinidine effects in Caucasians and Asians of both sexes.
    III. Methods: The Simcyp Population Based Simulator was used to simulate the..

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Last update 4 October 2019

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