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Formulation and development of chitosan based in situ thermosensitive injectable hydrogel of pegylated melphalan conjugates

  • At: 2014 FIP Congress in Bangkok (Thailand)
  • Type: Poster
  • By: SARAF, Shailendra (University Institute of Pharmacy, Pharmacy, Raipur, chhattisgarh, India)
  • Co-author(s): Saraf, Swarnlata (University Institute of Pharmacy, Raipur, chhattisgarh, India)
    Alexander, Amit (University Institute of Pharmacy, Raipur, chhattisgarh, India)
  • Abstract:

    Background:
    To reduce the burst effect and to provide a controlled release, a blend of Chitosan(CS)/glycerophosphate disodium (GP) thermosensitive hydrogels were prepared for the sustained delivery of an alkylating agent, melphalan (ML).
    Aim:
    In the present study, poorly soluble alkylating drug, melphalan (ML) is PEGylated with linear methoxy poly ..

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Last update 4 October 2019

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