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Docking studies, synthesis, characterization and evaluation of antitumor activity of some novel thiazine substituted 9-anilinoacridines and their 3d qsar studies

  • At: 2014 FIP Congress in Bangkok (Thailand)
  • Type: Poster
  • By: RAJAGOPAL, Kalirajan (JSS College of Pharmacy, Department of Pharmaceutical Chemistry, The nilgiris, India)
  • Co-author(s): Sundaram, Sankar (JSS College of Pharmacy, The nilgiris, India)
    Selvaraj, Jubie (JSS College of Pharmacy, Ootacamund, India)
  • Abstract:

    Background information:
    Acridine analogues bearing substituted bulky 9-amino functionalities are shown to inhibit topoisomerase II, relaxation of super coiled DNA are important drugs in treatment of cancer.
    Aims
    Based on the above background, A series of novel thiazine substituted 9-anilinoacridines were synthesized and evaluated for antitumor..

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Last update 4 October 2019

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