Azathioprine induced pancytopenia
- At: 2006 FIP Congress in Salvadore (Brazil)
- Type: Poster
- By: CHANG, Mei-Hui (Chang gung memorial hospital, Taoyuan, China Taiwan)
- Co-author(s): Deng, Shin Tarng (Chang gung memorial hospital, TAOYUAN, China Taiwan)
Azathioprine(AZA)is an imidazolyl derivative of 6-mercaptopurine that impairs DNA and RNA synthesis, it is shown to decrease the relapse rate in multiple sclerosis. AZA induced bone marrow toxicity may be dose related or well known thiopurine methyltransferase (TPMT) deficiency resulting in intracellular accumulation of cytotoxic thioguanine.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.