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Development and validation of a new lc-ms/ms method for the quantitation of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids in human serum

  • At: 2014 FIP Congress in Bangkok (Thailand)
  • Type: Poster
  • By: SENDA, Asuna (Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Japan)
  • Co-author(s): Sakai, Hitomi (Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Japan)
    Shiina, Daisuke (Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Japan)
    Mukai, Yuji (Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Japan)
    Toda, Takaki (Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Japan)
    Inotsume, Nobuo (Hokkaido Pharmaceutical University School of Pharmacy, Otaru, Japan)
  • Abstract:

    Background
    Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid (AA) that play important biological roles in anti-inflammatory processes, myocardial preconditioning, and blood pressure regulation. EETs are further metabolized to dihydroxyeicosatrienoic acids (DHETs). We developed a liquid chromatography-tandem mass spectrometry..

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Last update 4 October 2019

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