Population-based methods to guide dosage adjustments
- At: 2014 FIP Congress in Bangkok (Thailand)
- Type: Presentation
- By: MASUDA, Satohiro (Kyushu University Hospital, Pharmacy, Fukuoka, Japan)
- Co-author(s): Matsubara, Kazuo (Kyoto University Hospital, Kyoto, Japan)
Uemoto, Shinji (Kyoto University Hospital, Kyoto, Japan)
I. Background Because of a large inter-individual variation in the pharmacokinetics, individualized dosage regimens of tacrolimus and cyclosporine have not been established except for the TDM-based dosage modification. Recently, efflux pump P-glycoprotein (MDR1/ABCB1) and CYP3A4/5 in the intestine as well as the liver were identified to affect.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.