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Population-based methods to guide dosage adjustments

  • At: 2014 FIP Congress in Bangkok (Thailand)
  • Type: Presentation
  • By: MASUDA, Satohiro (Kyushu University Hospital, Pharmacy, Fukuoka, Japan)
  • Co-author(s): Matsubara, Kazuo (Kyoto University Hospital, Kyoto, Japan)
    Uemoto, Shinji (Kyoto University Hospital, Kyoto, Japan)
  • Abstract:

    I. Background Because of a large inter-individual variation in the pharmacokinetics, individualized dosage regimens of tacrolimus and cyclosporine have not been established except for the TDM-based dosage modification. Recently, efflux pump P-glycoprotein (MDR1/ABCB1) and CYP3A4/5 in the intestine as well as the liver were identified to affect


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Last update 4 October 2019

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