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Fatty acid ester prodrug: a prototype for future drug delivery system without systemic absorption

  • At: 2006 FIP Congress in Salvadore (Brazil)
  • Type: Poster
  • By: YONG, Chul Soon (College of Pharmacy, Yeungnam University, Gyeongsan-si, South-Korea)
  • Co-author(s): Choi, Han-Gon (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Yoo, Bong-Kyu (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Kim, Jung-Ae (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Lyoo, Won Seok (School of Textiles, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Choi, Jun-Young (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Piao, Ming-Guan (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Li, Dong-Xun (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Xuan, Jing-Ji (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Bhandari, Krishna Hari (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Newa, Madhuri (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
    Kwak, Mi-Kyoung (College of Pharmacy, Yeungnam University, GYEONGSAN-SI, South-Korea)
  • Abstract:

    Fatty acid esters of a model drug ketorolac were synthesized and confirmed to be prodrugs by performing enzymatic hydrolysis in rat skin and liver homogenate and plasma. Their pharmaceutical suitability was determined by studying their stability in pH 3.0 to 11.0, and the possibility of their systemic absorption was evaluated by skin permeation..

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Last update 4 October 2019

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