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Crystal structures of hiv-1 co-receptors ccr5 and cxcr4: implications for anti-hiv drug discovery

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Presentation
  • By: WU, Beili (Shanghai Institute of Materia Medica, Shanghai, China)
  • Co-author(s): Tan, Qiuxiang (Shanghai Institute of Materia Medica, Shanghai, China)
    Zhu, Ya (Shanghai Institute of Materia Medica, Shanghai, China)
    Zhao, Qiang (Shanghai Institute of Materia Medica, Shanghai, China)
  • Abstract:

    Chemokine receptors are critical regulators of cell migration in the context of immune surveillance, inflammation and development. The G protein-coupled chemokine receptors, CXCR4 and CCR5, act as co-receptors of Human Immunodeficiency Virus-1 (HIV-1) infection. Here we report five independent crystal structures of CXCR4 bound to an antagonist..

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Last update 4 October 2019

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