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An aptamer-based sirna in vivo delivery system targeting cancer stem cells

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Presentation
  • By: WANG, Tao (Deakin University, Medical school, Geelong, Australia)
  • Co-author(s): Shigdar, Sarah (Deakin University, Geelong, Australia)
    Marappan, Manju (Deakin University, Geelong, Australia)
    Xiang, Dongxi (Deakin University, Geelong, Australia)
    Radwan Raji al Shamaileh, Hadi (Deakin University, Geelong, Australia)
    Chen, Lijue (Deakin University, Geelong, Australia)
    Macdonald, Joanna (Deakin University, Geelong, Australia)
    Duan, Wei (Deakin University, Geelong, Australia)
    Hasimu, Hamulati (Deakin University, Geelong, Australia)
  • Abstract:

    Background: Two factors weigh heavily against the application of siRNA in cancer therapy. One is the lack of specificity and efficiency, another is the immune response associated with siRNA in vivo deliver systems. The aptamer directed siRNA in vivo delivery system was first developed in 2005 and combines two important advancements in the..

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Last update 4 October 2019

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