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Impact of inflammation and concomitant glucocorticoid on pharmacokinetic disposition of voriconazole and itraconazole in immunocompromised patients

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Presentation
  • By: NAITO, Takafumi (Hamamatsu University School of Medicine, Department of Hospital Pharmacy, Hamamatsu, Japan)
  • Co-author(s): Yamada, Takahiro (Hamamatsu University School of Medicine, Hamamatsu, Japan)
    Mino, Yasuaki (Hamamatsu University School of Medicine, Hamamatsu, Japan)
    Kawakami, Junichi (Hamamatsu University School of Medicine, Hamamatsu, Japan)
  • Abstract:

    Background: Inflammatory response decreases the expression of hepatic CYP3A, while glucocorticoid increases it. Impact of inflammation and concomitant glucocorticoid on pharmacokinetics of triazole antifungals have not been fully clarified in clinical settings.
    Aims: The aim of this study was to evaluate the pharmacokinetic disposition of..

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Last update 4 October 2019

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