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Investigating the structural and thermodynamic basis of substrate selectivities of human cytochrome p450 enzymes: a molecular dynamics study

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Presentation
  • By: NAIR, Pramod (Flinders University of South Australia, Clinical Pharmacology, Adelaide, Australia)
  • Co-author(s): Miners, John O. (Flinders University of South Australia, Adelaide, Australia)
  • Abstract:

    Enzymes of the cytochrome P450 (CYP) superfamily are responsible for the metabolism of a myriad of compounds that include drugs, non-drug xenobiotics (e.g. environmental chemicals), and endogenous compounds. The individual P450 enzymes exhibit characteristic substrate and inhibitor selectivities, and enzyme activities are variably affected by age, ..

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Last update 4 October 2019

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