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Ex-vivo and in vivo sirna delivery to activated t cells as novel anti-inflammatory asthma therapy

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Presentation
  • By: MERKEL, Olivia (Wayne State University, Pharmaceutical Sciences, Detroit, United States of America)
  • Co-author(s): Kim, Na Hyung (Wayne State University, Detroit, United States of America)
    Nadithe, Venkatareddy (Wayne State University, Detroit, United States of America)
    Thakur, Archana (Wayne State University, Detroit, United States of America)
    Lum, Lawrence (Wayne State University, Detroit, United States of America)
    Bassett, David J.P. (Wayne State University, Detroit, United States of America)
    Xie, Yuran (Wayne State University, Detroit, United States of America)
  • Abstract:

    Local, targeted, cell-specific RNA interference (RNAi)-based therapies could improve patients' ability to control asthma. Allergen-induced airway dysfunction was shown to be prevented by downregulating the secretion of Th2 cytokines. However, T cells are hard to transfect cells and not easily accessible for RNAi-based therapies. We recently..

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Last update 4 October 2019

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