Amyloid-ß and tau - a toxic pas de deux in Alzheimer's disease
- At: 2014 FIP Congress in PSWC, Melbourne (Australia)
- Type: Presentation
- By: GöTZ, Jürgen (The University of Queensland, Clem Jones Centre for Ageing Dementia Research (CJCADR) at the Queensland Brain, St lucia campus, Australia)
Amyloid-β (Aβ) and TAU are the two key molecules implicated in Alzheimer's disease. In a pathocascade, Aβ has been placed upstream of TAU. This concept has been proven in P301L mutant TAU transgenic mice that develop an increased number of tau tangles, either by crossing them with Aβ plaque-forming transgenic mice, or by intracerebral injections.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.