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Effects of lipid digestion on the phase behaviour of intestinal mixed micelles: correlation of in vitro studies with and in silico molecular dynamics simulation

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Presentation
  • By: POUTON, Colin (Monash University, Monash Institute of Pharmaceutical Sciences, Parkville, Australia)
  • Co-author(s): Birru, Woldeamanuel (Monash University, Parkville, Australia)
    Warren, Dallas (Monash University, Parkville, Australia)
    Porter, Chris (Monash University, Parkville, Australia)
    Benameur, Hassan (Capsugel, Illkirch, France)
    Chalmers, David (Monash University, Parkville, Australia)
  • Abstract:

    I Background: The bioavailability of poorly water-soluble drugs from the intestine can be improved by formulation in lipid-based delivery systems. Such formulations are known to be subject to digestion in the intestine. The association structures that are formed in the gut lumen are thought to have a significant influence on drug solubilisation..

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Last update 4 October 2019

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