The sequestration of drugs in lysosomes: mechanisms and therapeutic consequences
- At: 2014 FIP Congress in PSWC, Melbourne (Australia)
- Type: Presentation
- By: KRISE, Jeffrey (Univerisity of Kansas, Pharmaceutical Chemistry, Lawrence, ks, United States of America)
Weakly basic, amine-containing molecules are pervasive across a variety of therapeutic drug classifications. For many decades it has been known that such weakly basic compounds have the propensity be sequestered into acidic organelles such as lysosomes according to an ion trapping-type mechanism. More recently, an interest in understanding the.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.