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The sequestration of drugs in lysosomes: mechanisms and therapeutic consequences

  • At: PSWC, Melbourne (Australia) (2014)
  • Type: Presentation
  • By: KRISE, Jeffrey (Univerisity of Kansas, Pharmaceutical Chemistry, Lawrence, ks, United States of America)
  • Abstract:

    Weakly basic, amine-containing molecules are pervasive across a variety of therapeutic drug classifications. For many decades it has been known that such weakly basic compounds have the propensity be sequestered into acidic organelles such as lysosomes according to an ion trapping-type mechanism. More recently, an interest in understanding the..

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Last update 4 October 2019

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