The association between ugt1a1*28 and survival after irinotecan chemotherapy: a collaborative systematic review and meta-analysis
- At: PSWC, Melbourne (Australia) (2014)
- Type: Poster
- By: DIAS, Mafalda M. (University of South Australia, School of Pharmacy and Medical Sciences, Adelaide, Australia)
- Co-author(s): Mckinnon, Ross A. (Flinders University, Adelaide, Australia)
Sorich, Michael J. (Flinders University, Adelaide, Australia)
Background: Individuals possessing uridine diphosphate-glucuronosyltransferase (UGT) 1A1*28 alleles have a greater risk of developing irinotecan-related toxicity (neutropenia and diarrhoea), compared with patients without these alleles. It has been proposed that UGT1A1*28 genotyping may be used to pre-emptively dose reduce irinotecan for UGT1A1*28 .. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.