Preclinical safety assessment of substrates for human p-glycoprotein: bioinformatics-assisted selection of

• In: Posters J - Translational Research and Individualized Medicines
• At: PSWC, Melbourne (Australia) (2014)
• Type: Poster
• Poster code: PJ-004
• By: PAULETTI, Giovanni M. (University of Cincinnati, James L. Winkle College of Pharmacy, Cincinnati, United States of America)
• Co-author(s): Pal, Ramavati (University of Cincinnati, Cincinnati, United States of America)
  Menon, Anil (University of Cincinnati, Cincinnati, United States of America)
  
• Abstract:

  Background: Regulatory standards mandate preclinical safety assessment of new molecular entities in two [quotright]relevant[quotrightB]animal species prior to first-in-human studies. To assist in rational selection of [quotright]relevant[quotrightB]animal species, P-glycoprotein (P-gp) primary sequences for human and common preclinical animal..

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