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Preclinical safety assessment of substrates for human p-glycoprotein: bioinformatics-assisted selection of

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: PAULETTI, Giovanni M. (University of Cincinnati, James L. Winkle College of Pharmacy, Cincinnati, United States of America)
  • Co-author(s): Pal, Ramavati (University of Cincinnati, Cincinnati, United States of America)
    Menon, Anil (University of Cincinnati, Cincinnati, United States of America)
  • Abstract:

    Background: Regulatory standards mandate preclinical safety assessment of new molecular entities in two [quotright]relevant[quotrightB]animal species prior to first-in-human studies. To assist in rational selection of [quotright]relevant[quotrightB]animal species, P-glycoprotein (P-gp) primary sequences for human and common preclinical animal..

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Last update 4 October 2019

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