Preclinical safety assessment of substrates for human p-glycoprotein: bioinformatics-assisted selection of
- At: 2014 FIP Congress in PSWC, Melbourne (Australia)
- Type: Poster
- By: PAULETTI, Giovanni M. (University of Cincinnati, James L. Winkle College of Pharmacy, Cincinnati, United States of America)
- Co-author(s): Pal, Ramavati (University of Cincinnati, Cincinnati, United States of America)
Menon, Anil (University of Cincinnati, Cincinnati, United States of America)
Background: Regulatory standards mandate preclinical safety assessment of new molecular entities in two [quotright]relevant[quotrightB]animal species prior to first-in-human studies. To assist in rational selection of [quotright]relevant[quotrightB]animal species, P-glycoprotein (P-gp) primary sequences for human and common preclinical animal.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.