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Thiopurine s-methyltransferase (tpmt) phenotypes in the nigerian population

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: BOLAJI, Oluseye (Obafemi Awolowo University, Department of Pharmaceutical Chemistry, Ile-ife, Nigeria)
  • Co-author(s): Adehin, Ayo (Obafemi Awolowo University, Ile-ife, Nigeria)
  • Abstract:

    Background: Thiopurine S-methyltransferase (TPMT), a polymorphic enzyme, catalyses the methylation of thiopurine drugs. Mild to severe myelosuppression, at times lethal, are characteristic of certain phenotypes.
    Aim:This study investigated TPMT phenotypes in a Nigerian population in order to derive reference values for the enzyme's activity in the ..

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Last update 4 October 2019

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