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Comparing the solubility of three poorly soluble apis in conventional and new biorelevant media with human intestinal fluid

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: FUCHS, Alexander (Goethe University Frankfurt am Main, Institute for Pharmaceutical Technologie, Frankfurt am main, Germany)
  • Co-author(s): Kl, Bastian (Biorelevant.com Ltd, Croydon, United Kingdom)
    Leigh, Mathew (Biorelevant.com Ltd, Croydon, United Kingdom)
    Dressman, Jennifer B. (Goethe University Frankfurt am Main, Frankfurt am main, Germany)
  • Abstract:

    BACKGROUND: FaSSIF and FaSSIF-V2 are commonly used to simulate the physiological composition of human intestinal fluids (HIF) in in vitro solubility and dissolution studies. In comparison to the previously used SDS buffers, these media are able to better reflect the solubility of poorly soluble APIs.
    AIM: Evaluating the influence of different bile ..

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Last update 4 October 2019

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