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L-ornithin-l-aspartate overexpresses bax levels to illustrate hepaptoprotective action: an in vitro and in vivo investigation

  • At: 2014 FIP Congress in PSWC, Melbourne (Australia)
  • Type: Poster
  • By: JAIN, Prateek (Manipal College of Pharmaceutical Sciences, Manipal University, Pharmaceutical Biotechnology, Manipal, karnataka, India)
  • Co-author(s): Udupa, Nayanabhirama (Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, karnataka, India)
    Raj P, Vasanth (Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, karnataka, India)
    Kumar, Nitesh (Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, karnataka, India)
    Rao C, Mallikarjuna (Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, karnataka, India)
  • Abstract:

    Background
    Ornithine aspartate has been shown to be beneficial in people with hepatic encephalopathy and liver cirrhosis. Bax and bcl-2 are the two main genes involved in maintaining the mitochondrial integrity.
    Aim
    To examine the hepatoprotective activity of L-Ornithine-L-Aspartate (LOLA) with respect to mitochondrial pathway in Chang liver cells
    ..

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Last update 4 October 2019

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