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Prediction of the clinical risk of drug-induced cholestatic liver injury from in vitro rat sandwich cultured hepatocytes assay.

  • In: Posters G - Pharmacokinetics (PK), Pharmacodynamics (PD) and Systems Pharmacology
  • At: PSWC, Melbourne (Australia) (2014)
  • Type: Poster
  • Poster code: PG-044
  • By: ITO, Kousei (Chiba University, Graduate School of Pharmaceuticak Sciences, Chiba, Japan)
  • Co-author(s): Nozaki, Mayuka (Chiba University, Chiba, Japan)
    Horie, Toshiharu (Teikyo Heisei University, Tokyo, Japan)
    Sekine, Shuichi (Chiba University, Chiba, Japan)
  • Abstract:

    [Background&Aim] It is important to assess the risk of drug induced liver injury (DILI) during the preclinical drug development process. We have established a rat sandwich cultured hepatocytes (rSCHs) based assay system to evaluate cholestatic DILI risk of each drug compound. However, it has not yet been confirmed if this in vitro assay system..

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Last update 4 October 2019

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