Involvement of caveolin-1 tyrosine 14 and src tyrosine 419 phosphorylation levels in intrinsic p-glycoprotein transport function at human blood-brain barrier

• In: Posters G - Pharmacokinetics (PK), Pharmacodynamics (PD) and Systems Pharmacology
• At: PSWC, Melbourne (Australia) (2014)
• Type: Poster
• Poster code: PG-043
• By: HOSHI, Yutaro (Graduate School of Pharmaceutical Sciences, Tohoku University, Division of Membrane Transport and Drug Targeting, Sendai, Japan)
• Co-author(s): Uchida, Yasuo (Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan)
  Tachikawa, Masanori (Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan)
  Ohtsuki, Sumio (Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan)
  Terasaki, Tetsuya (Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan)
  
• Abstract:

  [Purpose] P-glycoprotein (P-gp) transport activity at the blood-brain barrier (BBB) is altered with and without the changes in the protein levels under disease conditions. The purpose of this study was to clarify the mechanisms regulating the intrinsic P-gp efflux activity by phosphoproteomics. [Methods] Human brain capillary endothelial cell line ..

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