Optimization of spray dried microspheres for pulmonary inhalation development: exploring a new drug delivery route for melatonin
- In: Posters D - Formulation Design and Pharmaceutical Technology
- At: PSWC, Melbourne (Australia) (2014)
- Type: Poster
- Poster code: PD-126
- By: ZHAO, Min (UCL School of Pharmacy, Department of Pharmaceutics, London, United Kingdom)
- Co-author(s): Samaro, Aseel (UCL School of Pharmacy, London, United Kingdom)
Orlu Gul, Mine (UCL School of Pharmacy, London, United Kingdom)
Casati, Federica (UCL School of Pharmacy, London, United Kingdom)
Background: Melatonin, a drug for the treatment of insomnia, has a very low oral bioavailability (15%) mainly due to the extensive first pass metabolism in the liver. This leads to great interest in establishing whether pulmonary dry powder inhalation (DPI) is a promising route to deliver melatonin as a means of improving the bioavailability.
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