Characterisation of the guanylate cyclase catalytic activity in irak3

• In: Posters C - Drug Design and Discovery
• At: PSWC, Melbourne (Australia) (2014)
• Type: Poster
• Poster code: PC-018
• By: FREIHAT, Lubna (Monash University, Drug discovery biology, Melbourne, Australia)
• Co-author(s): Wheeler, Janet I. (Monash University, Melbourne, Australia)
  Manallack, David T (Monash University, Melbourne, Australia)
  Irving, Helen R. (Monash University, Melbourne, Australia)
  
• Abstract:

  IRAK3 (interleukin-1 receptor associated kinase 3) is an important negative regulator of inflammation and is critical in maintaining homeostasis in the innate immune response. The selectivity of IRAK3 and its exact mechanism of action are not fully understood. IRAK3 was unearthed as a potential novel guanylate cyclase (GC) using a GC specific..

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