Transforming toxins into therapeutics: potassium channel blockers as treatments for autoimmune diseases
- At: 2014 FIP Congress in PSWC, Melbourne (Australia)
- Type: Presentation
- By: NORTON, Raymond Stanley (Monash Institute of Pharmaceutical Sciences, Medicinal Chemistry, Parkville, Australia)
Background: Effector memory T cells, which are involved in autoimmune diseases such as multiple sclerosis (MS), type 1 diabetes mellitus and rheumatoid arthritis (RA), express Kv1.3 potassium channels, which play a major role in their activation. Blockers of lymphocyte Kv1.3 channels selectively inhibit the activation of these cells and therefore.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.