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Design, synthesis, and biological evaluation of memantine-polyamine conjugates as NMDA channel blockers

  • In: SIG Posters
  • At: Amsterdam (the Netherlands) (2012)
  • Type: Poster
  • Poster code: DDD-P-14
  • By: KUMAMOTO, Takuya (Musashino University, Faculty of Pharmaceutical Sciences, Nishitokyo, Japan)
  • Co-author(s): Yoshizawa, Y. (Chiba University, Chiba, Japan)
    Higashi, K. (Chiba University, Chiba, Japan)
    Nishimura, K. (Chiba University, Chiba, Japan)
    Toida, K. (Chiba University, Chiba, Japan)
    Ishikawa, T. (Chiba University, Chiba, Japan)
    Katakawa, K. (Musashino University, Nishitokyo, Japan)
    Igarashi, K. (Amine Pharma, Chiba, Japan)
  • Abstract:

    1. Background

    -Methyl-D-aspartate (NMDA) receptors have been implicated in learning and memory, and may also play a central role in various conditions leading to neuronal degradation. Overexcitation of NMDA receptors may result in neuronal cell injury or death. Therefore, NMDA receptor antagonists could be of therapeutic benefit to a number of


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Last update 28 September 2023

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