A modified LC-MS/MS method for determination of tetramethylpyrazine in microdialysis samples and calibration of home-made linear probes

• In: SIG Posters
• At: Amsterdam (the Netherlands) (2012)
• Type: Poster
• Poster code: PAA-P-03
• By: HU, Jin Hong (Shanghai Changhai Hospital,, Department of Pharmacy,, Shanghai, China)
• Co-author(s): Han, J.Z. (Shanghai Changhai Hospital,, Shanghai, China)
  Sun, J. (Shanghai Changhai Hospital,, Shanghai, China)
  
• Abstract:

  
  Background:
  Tetramethylpyrazine (TMP) is one of the most important active ingredients of a Chinese herb Ligusticum wallichii Franchat, which is widely used for the treatment of cardiovascular diseases. Several factors may affect TMP exposure after topical administration, resulting in large variability and demanding further elucidation of drug

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