Quantitative effect of cyp2c19 and cyp2c9 genotype on concentration prediction of valproate in epileptic patients

• In: Individualised Medicine Posters
• At: Hyderabad (India) (2011)
• Type: Poster
• Poster code: IM-P-06
• By: JIANG, Dechun (Department of Pharmacy, Xuanwu Hospital of Capital Medical University, Beijing, China)
• Co-author(s): Bai, XiangRong (Department of Pharmacy, XuanWu Hospital of Capital Medical University, Beijing, China)
  Zhang, QingXia (Department of Pharmacy, XuanWu Hospital of Capital Medical University, Beijing, China)
  Wang, YuQin (Department of Pharmacy, XuanWu Hospital of Capital Medical University, Beijing, China)
  Lu, Wei (School of Pharmaceutical Science, Peking University, Beijing, China)
  Li, Lin (Department of Pharmacology, XuanWu Hospital of Capital Medical University, Beijing, China)
  Zeitlinger, Markus (Department of Clinical Pharmacology, Vienna Medical University, Vienna, Austria)
  Wang, Yawei (Department of Pharmacy, XuanWu Hospital of Capital Medical University, Beijing, China)
  
• Abstract:

  Background: Valproate (VPA) is a typical antiepileptic drug which is effective on various seizures. The application of VPA is so difficult to handle because of the significant individual pharmacokinetic variability. It is important to monitor the serum VPA concentration and carry out the individual therapy. However, how about the influence of..

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