Rapid determination of clobazam and desmethylclobazam in human plasma by HPLC

• In: SIG Bioavailability / Bioequivalence - Poster Session
• At: Cairo (Egypt) (2005)
• Type: Poster
• Poster code: BB-P-015
• By: ROUINI, Mohammadreza (Tehran U of Medical Sciences, Pharmaceutics, Tehran, Iran)
• Co-author(s): Hosseinzadeh Ardakani (Tehran U of Medical Sciences, Tehran, Iran)
  Mokhberi (Tehran U of Medical Sciences, Tehran, Iran)
  Badri (Tehran U of Medical Sciences, Tehran, Iran)
  
• Abstract:

  Aim: The study was designed to develop a rapid HPLC method using Chromolith TM column for sensitive determination of clobazam (CLB) and its main metabolite N-desmethylclobazam (NDCLB/IS) in human plasma with an acceptable LOQ for pharmacokinetic studies. Methods: The chromatographic apparatus consisted of a low-pressure gradient HPLC pump, a UV

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