Differences in cytochrome p450 and nuclear receptor mrna levels in liver and small intestines between sd and da rats

• At: 2009 FIP Congress in Istanbul (Turkey)
• Type: Poster
• By: MASAHIRO, Iwaki (Kinki University, Osaka, Japan)
• Co-author(s): Atsushi, Kawase (Kinki University, OSAKA, Japan)
  Akiyuki, Fujii (Kinki University, OSAKA, Japan)
  Ryosuke, Akai (Kinki University, OSAKA, Japan)
  
• Abstract:

  This study aimed to clarify the differences in mRNA levels of cytochrome P450 (CYP) isoforms and nuclear receptors between Dark Agouti (DA) and Sprague-Dawley (SD) rats which are animal models for poor metabolizers and extensive metabolizers for CYP2D6, respectively. Using liver and small intestine tissues of both rat strains, we investigated the ..

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