Effect of gender on the pharmacokinetics of indapamide in healthy volunteers

• In: Bioavailability/Bioequivalence - Posters
• At: Istanbul (Turkey) (2009)
• Type: Poster
• Poster code: BB-P-003
• By: KHOLOVA, Dagmar (Institute of Experimental Biopharmaceutics, Hradec Kralove, Czech Republic)
• Co-author(s): Vyslouzil, Ladislav (Institute of Experimental Biopharmaceutics, HRADEC KRALOVE, Czech Republic)
  Kopecky, Jiri (Institute of Experimental Biopharmaceutics, HRADEC KRALOVE, Czech Republic)
  Macek, Karel (Teaching Hospital, HRADEC KRALOVE, Czech Republic)
  Kubant, Pavel (Institute of Experimental Biopharmaceutics, HRADEC KRALOVE, Czech Republic)
  Chladek, Jaroslav (Institute of Experimental Biopharmaceutics, HRADEC KRALOVE, Czech Republic)
  Kvetina, Jaroslav (Institute of Experimental Biopharmaceutics, HRADEC KRALOVE, Czech Republic)
  
• Abstract:

  Sex differences in the pharmacokinetics have been described in many drugs (Harris et al., 1995). The aim of our study was to find out the effect of gender on the pharmacokinetics of diuretic and antihypertensive drug indapamide. Indapamide was given to 11 healthy men
  
  (18-43 years, 65-96 kg) and 13 healthy women (22-55 years, 53-83 kg) in single..

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