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Therapy-related determinants of medication non-adherence: a systematic review protocol.

  • At: PPR 2022 (2022)
  • Type: Poster
  • Poster code: PM-15
  • By: GONZáLEZ, Adriana (Pharmaceutical Care Research Group, University of Granada, Granada, Spain)
  • Co-author(s): Adriana González, PhD Student, Universidad De Granada, Spain
    Shalom Benrimoj, Member of Pharmaceutical Care Research Group, University of Granada, Pharmaceutical Care Research Group, University of Granada, Granada, Spain
    Fernando Martinez, Main Researcher of Pharmaceutical Care Research Group, University of Granada, Pharmaceutical Care Research Group, University of Granada, Granada, Spain
    Victoria García, Lecturer in Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, Australia



  • Abstract:

    Therapy-related determinants of medication non-adherence: a systematic review protocol.

    Adriana González a, Shalom I. Benrimoj a, Fernando Martinez-Martinez a, Victoria Garcia-Cardenas b

    a Pharmaceutical Care Research Group, University of Granada, Granada, Spain
    b Graduate School of Health, University of Technology Sydney, Sydney, Australia

    Background: medication non-adherence is a complex and multifactorial problem which places a significant cost burden on healthcare systems. According to the World Health Organisation, determinants of non-adherence can be classified into five dimensions which include: patient-related factors, clinical condition-related factors, socioeconomic factors, therapy-related factors and healthcare system-related factors. Despite the availability of studies on medication adherence determinants, conflicting evidence exists specifically on therapy-related determinants (e.g., drug frequency, drug regimen, side effects, time since diagnosis, time since treatment) and their association with medication non-adherence.

    Purpose: the proposed systematic review aims to synthesise the most recent evidence on determinants of medication non-adherence, specifically the ones which belong to therapy-related factors.

    Method: a systematic review will be performed and reported according to PRISMA guidelines. PubMed, EMBASE, Web of Science, Cochrane and PsycINFO will be searched using a predefined search strategy. Studies will be included in the review if available in English full text. Titles and abstracts will be screened and full text articles will be screened by two independent reviewers. Inclusion and exclusion criteria will be applied to select eligible articles and a methodological quality assessment will be conducted. Data extraction will be done using a predefined extraction structure.

    Results/ Current study status: The database search is being conducted. It is expected that full-text screening will be completed in July 2022. The following outcomes will be reported: therapy-related determinants of medication non-adherence, identified among the most recent scientific research.

    Conclusion/Expected outcomes: the expected outcomes from this systematic review include the determinants of medication non-adherence, particularly the therapy-related ones. Different factors associated with the therapy may be identified. This study will provide clear evidence that medication adherence is affected by multiple modifiable therapy-related determinants. Therefore, numerous interventions may be performed by different healthcare professionals to improve medication adherence.

Last update 4 October 2019

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