Synthesis and pharmacological evaluation of alkylene-linked bis-pyridinium monooximes as possible antidotes in organophosphate pesticide poisoning.
- At: 2004 FIP Congress in New Orleans (USA)
- Type: Poster
- By: CHENNAMANENI, Chennamaneni Sriniv (University College of Pharm.Sciences, NDDS Laboratory, Andhra Pradesh, India)
- Co-author(s): Vobalaboina, Venkateswarlu (Kakatiya University, India)
Garlapati, Achaiah (University College of Pharm.Sciences, India)
Introduction: Organohposphorous compounds have been used as chemical weapons and as pesticides. The mechanism of organophosphate poisoning involves phosphorylation of a serine hydroxyl group in the active site of acetylcholinesterase (AchE), leading to inactivation of this essential enzyme. The therapeutic approach to organophosphate poisoning is.. The access to the whole abstract and the presentation file is available to FIP members and to congress participants of that specific congress.