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Inhibition of t cell proliferation by dictyostelium differentiation-inducing factors-1

  • At: 2018 FIP Congress in Glasgow (Scotland)
  • Type: Poster
  • By: ZHOU, Jian-Rong (Sojo University)
  • Co-author(s): Jian-Rong Zhou
  • Abstract:

    Background

    T cell play a central role in adaptive immune response. Differentiation-inducing factor-1 (DIF-1), a chlorinated alkylphenone, was found in the cellular slime mold Dictyostelium discoideum. DIF derivatives were found to promote mitogen-activated IL-2 production via AP-1 in Jurkat cells, while the effect on primary T cell is not yet..

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Last update 4 October 2019

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