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Analysis of physicochemical properties of self-nanoemulsion constructed from environment sensitive ionizable lipid

  • In: Poster Presentation
  • At: Stockholm (Sweden) (2017)
  • Type: Poster
  • Poster code: P-A-070-Tuesday
  • By: TANAKA, Hiroki (Hokkaido University, Faculty of Pharmaceutical Scieces, Sapporo, Japan)
  • Co-author(s): Hiroki Tanaka: Faculty of Pharmaceutical Scieces, Hokkaido University, Sapporo, Japan
    Sho Oasa: Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan
    Masataka Kinjo: Faculty of Advanced Life Science, Hokkaido University, Sapporo, Japan
    Kota Tange: NOF Corporation, Kawasaki, Japan
    Yuta Nakai: NOF Corporation, Kawasaki, Japan
    Hideyoshi Harashima: Faculty of Pharmaceutical Scieces, Hokkaido University, Sapporo, Japan
    Hidetaka Akita: Faculty of Pharmaceutical Scieces, Chiba University, Chiba, Japan
  • Abstract:

    Backgrounds

    Ionizable lipids with tertiary amines have been developed as promising materials for nucleic acid therapy. Neutral surface of a carrier formed with an ionizable lipid is advantageous to its pharmacokinetics/intracellular trafficking since unspecific electrostatic interaction with biomaterials can be avoided. Furthermore, an ionizable..

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Last update 28 September 2023

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