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Approaches to up-regulate P-glycoprotein for the treatment of Alzheimer's disease

  • In: Poster Presentation
  • At: Stockholm (Sweden) (2017)
  • Type: Poster
  • Poster code: P-A-016-Tuesday
  • By: NEWMAN, Stephanie (Melbourne, Australia)
  • Co-author(s): Stephanie Newman: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia
    Yijun Pan: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia
    Jennifer Short: Drug Discovery Biology, Monash University, Melbourne, Australia
    Joseph Nicolazzo: Drug Delivery, Disposition and Dynamics, Monash University, Melbourne, Australia
  • Abstract:

    Backgrounds

    P-glycoprotein (P-gp) at the blood-brain barrier (BBB) mediates the brain-to-blood clearance of β-amyloid (Aβ) and is down-regulated in Alzheimer's disease (AD). Interestingly, the mood-stabilising drug lithium, has been associated with a reduced incidence of AD in humans. In vitro studies indicate that lithium chloride (LiCl) can..

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Last update 28 September 2023

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