Menu
  • Join
  • Login
  • Contact
 

Search abstracts / presentations


Exposure-response model for the effect of AZD5069, a novel CXCR2 antagonist, on neutrophil count in asthma patients

  • In: Poster Presentation
  • At: Stockholm (Sweden) (2017)
  • Type: Poster
  • Poster code: P-A-106-Monday
  • By: WAHLBY HAMREN, Ulrika (AstraZeneca R&D, Early Clinical Development, Mölndal, Sweden)
  • Co-author(s): Ulrika Wahlby Hamren: Quantitative Clinical Pharmacology, Early Clinical Development, AstraZeneca R&D, Gothenburg, Sweden
    Justin Wilkins: Occams, Amstelveen, Netherlands;, SGS Exprimo NV, Mechelem, Belgium
    Bengt Larsson: RIA TMU, Early Clinical Development, AstraZeneca R&D, Gothenburg, Sweden
    Marie Cullberg: Quantitative Clinical Pharmacology, Early Clinical Development, AstraZeneca R&D, Gothenburg, Sweden
  • Abstract:

    Backgrounds

    AZD5069 is a reversible oral CXCR2 antagonist that blocks neutrophil migration and reduces circulating neutrophil counts [1]. Models describing neutrophil dynamics after cytotoxic drug intervention have previously been published [2], however these are not applicable for the CXCR2 mechanism of action.

    Aims

    We developed a population

    ..

  • The access to the whole abstract and if available the presentation file is available to FIP members and to congress participants of that specific congress. Please login
Last update 28 September 2023

FIP Congresses