Characteristic pH-profiles of passive membrane permeability for chemical classes

• In: Poster Presentation
• At: Stockholm (Sweden) (2017)
• Type: Poster
• Poster code: P-A-031-Monday
• By: OJA, Mare (University of Tartu, Institute of Chemistry, Tartu, Estonia)
• Co-author(s): Mare Oja: Institute of Chemistry, University of Tartu, Tartu, Estonia
  Uko Maran: Institute of Chemistry, University of Tartu, Tartu, Estonia
  
• Abstract:

  Backgrounds

  Approved drugs include approximately 35% bases, 20% acids, 30% ampholytes and 15% neutrals. The properties of ionisable compounds are highly influenced by the pH of the environment. The pH range in gastrointestinal tract is from ~2 to ~9. Commonly absorption related properties, permeability and solubility, for drug candidates is..

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