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Production of the antimalarial drug precursor amorpha-4,11-diene and artemisinic acid in engineered yeast

  • At: Beijing (China) (2007)
  • Type: Poster
  • By: KONG, Jianqiang (Institute of Materia Medica, Beijing, China)
  • Co-author(s): Wang, wei (Institute of Materia Medica, BEIJING, China)
    Zhu, ping (Institute of Materia Medica, BEIJING, China)
    Dai, jungui (Institute of Materia Medica, BEIJING, China)
  • Abstract:

    Two genes encoding amorpha-4,11-diene synthase(ADS) and amorpha-4,11-diene hydroxylase (CYP71AV1 P450)were cloned from Artemisia annua L. The two genes were related to artemisinin biosynthesis. The other two genes encoding the FPP synthase and HMG-CoA reductase were cloned from Saccharomyces cerevisiae. All cloned cDNAs were confirmed by DNA..

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Last update 4 October 2019

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