Studies on design, synthesis and bioactivities of no-donating derivatives of puerarin

• At: 2007 FIP Congress in Beijing (China)
• Type: Poster
• By: SHI, Wei-bing (China Pharmaceutical University, Nanjing, China)
• Co-author(s): ZHANG, Yi-hua (China Pharmaceutical University, NANJING, China)
  LAI, Yi-sheng (China Pharmaceutical University, NANJING, China)
  JI, Hui (China Pharmaceutical University, NANJING, China)
  LI, Yong-qi (China Pharmaceutical University, NANJING, China)
  
• Abstract:

  OBJECTIVE To study synthesis and anti-hypertensive activity of NO-donating derivatives of puerarin and to search for novel anti- hypertensive agents with high activity and less side effects. METHOD The title compounds were synthesized by coupling of organic nitrate or furoxan with puerarin, and the inhibitory activity against KCl-induced..

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